Method and apparatus using IDS™ for multi-agent therapy
AssigneeThe RxFiles Corporation
InventorJohn P. McMichael
Life of this patent
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Abstract
A method and apparatus using IDS™ technology to calculate new agent doses in a multi-agent therapy. The overall proportion of each agent is determined by the amount of agent as it relates to the dosing range. The overall proportion as well as the intrinsic potency of the agent is used to determine the total proportional effect which each agent has on the surrogate marker. This parameter is then inserted into the four-parameter equation for calculating dose by adjusting the proportional change in marker that is attributed to the activity of the agent.
Claims12
A method of calculating the next best dose for each agent of a multi-agent therapy which a patient may be using, comprising the steps of:
- accepting as first inputs the patient's current doses of a plurality of agents which the patient may be using;
- accepting as second inputs one or more numerical markers indicating one or more responses of the patient;
- and
- calculating new agent doses for said plurality of agents as a function of said first inputs, said second inputs, and contributions each agent makes to an overall effect to be achieved by said multi-agent therapy.
A storage device having stored thereon an ordered set of instructions which, when executed by a computer, performs a predetermined method, comprising:
- first means for accepting as first inputs a patient's current doses of a plurality of agents which the patient may be using in a multi-agent therapy
- second means for accepting as second inputs one or more numerical markers indicating one or more responses of the patient;
- and
- third means for calculating new agent doses for said plurality of agents as a function of said first inputs, said second inputs, and contributions which each agent makes to an overall effect to be achieved by said multi-agent therapy.
An apparatus for calculating the next best dose for each agent of a multi-agent therapy which a patient may be using, comprising:
- first means for accepting as first inputs the patient's current doses of a plurality of agents which the patient may be using;
- second means for accepting as second inputs one or more numerical markers indicating one or more responses of the patient;
- and
- third means for calculating new agent doses for said plurality of agents as a function of said first inputs, said second inputs, and contributions which each agent makes to an overall effect to be achieved by said multi-agent therapy.
Dependencies are inferred from the claim text.