Z-styryl sulfone anticancer agents
AssigneeTemple University of the Commonwealth System of Higher Education
InventorsE. Premkumar Reddy, M. V. Ramana Reddy
Life of this patent
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Abstract
(Z)-styryl benzylsulfones of formula I are useful as anticancer agents: wherein R1 is selected from the group consisting of hydrogen, chloro and nitro; R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro; and R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro; provided that at least one of R1 or R2 is hydrogen. The corresponding (Z)-styryl benzylsulfides are useful as intermediates in the preparation of the biologically active (Z)-styryl benzyl sulfones.
Claims14
A compound of the formula
- wherein
- R1 is selected from the group consisting of hydrogen, chloro and nitro;
- R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro;
- R3 is selected from the group consisting of hydrogen, nitro, lower alkyl, chloro, bromo, iodo and fluoro;
- R4 is selected from the group consisting of hydrogen, nitro, chloro, bromo, iodo and fluoro
- provided:
- (a) at least one of R1 or R2 is hydrogen;
- (b) R1 and R2 may not both be hydrogen when:
- (i) R3 and R4 are both hydrogen,
- (ii) R3 is chloro and R4 is hydrogen, or
- (iii) R4 is chloro and R3 is hydrogen;
- and
- (c) when R1 is hydrogen and R2 is methyl:
- (i) both R3 and R4 may not be hydrogen,
- (ii) R3 may not be chloro when R4 is hydrogen, and
- (iii) R4 may not be chloro when R3 is hydrogen.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of the formula:
- wherein
- R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro;
- and
- R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro;
- provided at least one of R1 or R2 is hydrogen, and at least one of R2, R3 and R4 is iodo.
A compound of the formula
- wherein
- R1 is selected from the group consisting of hydrogen, chloro and nitro;
- R2 is selected from the group consisting of hydrogen, lower alkyl, lower alkoxy, chloro, bromo, iodo and fluoro;
- R3 and R4 are independently selected from the group consisting of hydrogen, lower alkyl, nitro, chloro, bromo, iodo and fluoro;
- provided:
- (a) at least one of R1 or R2 is hydrogen;
- (b) R1 and R2 may not both be hydrogen when:
- (i) R3 and R4 are both hydrogen,
- (ii) R3 is chloro and R4 is hydrogen, or
- (iii) R4 is chloro and R3 is hydrogen;
- and
- (c) when R1 is hydrogen and R2 is methyl:
- (i) both R3 and R4 may not be hydrogen,
- (ii) R3 may not be chloro when R4 is hydrogen, and
- (iii) R4 may not be chloro when R3 is hydrogen.
Dependencies are inferred from the claim text.