Triphenylalkene derivatives and their use as selective estrogen receptor modulators

A compound of the formula:

• wherein R1 is H, halogen, OCH3, or OH;
• R2 is selected from the group consisting of
• —Y—(CH2)nCH2—O—R6, 2,3-dihydroxypropoxy, 2-methylsulfamylethoxy, 2-chloroethoxy, 1-ethyl-2-hydroxyethoxy, 2,2-diethyl-2-hydroxyethoxy, and carboxymethoxy;
• where X is NH or S;
• n is an integer from 1 to 4;
• R4 and R5, which are the same or different, are a 1 to 4 carbon alkyl, H, —CH2C≡CH or —CH2CH2OH;
• or
• R4 and R5 form an N-containing five- or six-membered ring or heteroaromatic ring selected from the group consisting of an imidazole ring and a piperidine ring;
• Y is O, NH or S;
• and
• R6 is H, —CH2CH2OH, or —CH2CH2Cl;
• and
• R3 is H, halogen, OH or —OCH3;
• or a stereoisomer;
• or a non-toxic pharmaceutically acceptable salt or ester thereof or mixtures thereof,
• provided that
• when R2 is —O—CH2CH2—OH or —O—CH2COOH in the 4-position of the phenyl, then R1 and R3, cannot simultaneously be H, or OH in the 4-position of the phenyl;
• and
• if R1 is OH in the 4-position of the phenyl, R3 cannot be H.