Methods, systems, and computer program products for analyzing and presenting NMR lipoprotein-based risk assessment results

A computer program product for providing patient specific NMR-measured lipoprotein information, the computer program product comprising:

• a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising:
• computer readable program code for obtaining NMR-measurements for a plurality of lipoprotein subclass constituents including at least LDL particle size, LDL concentration, and large HDL concentration;
• computer readable program code for determining a coronary heart disease risk level associated with each of the plurality of NMR-measured lipoprotein subclass measurements;
• computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria;
• and
• computer readable program code for automatically generating a lipoprotein report for a plurality of patients with data corresponding to patient specific NMR-measured lipoprotein subclasses, the computer readable program code for generating the reports including computer readable program code for generating, for each reported measured subclass value, an adjacently positioned associated risk analysis portion according to predetermined risk criteria associated with the measured subclass value, with the risk for a measured value to be represented in the risk analysis portion in at least one of (i) a color-accentuated manner;
• (b) a different selected font relative to adjacent portions of the report;
• (c) bolded;
• (d) italicized;
• (e) circled;
• (f) boxed;
• (g) underlined;
• and (h) highlighted to thereby provide a contemporaneous reference guideline for interpretation of the measured lipoprotein subclass value.

A computer program product for providing patient specific NMR-measured lipoprotein information, the computer program product comprising:

• a computer readable storage medium having computer readable program code means embodied in said medium, said computer-readable program code means comprising:
• computer readable program code for obtaining NMR-measured measurements for a plurality of lipoprotein subclass constituents including at least LDL particle size, LDL concentration, and large HDL concentration;
• computer readable program code for determining a coronary heart disease risk level associated with each of the plurality of NMR-measured lipoprotein subclass measurements;
• computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria;
• and
• computer readable program code for automatically generating a lipoprotein report for a plurality of patients with data corresponding to patient specific NMR-measured lipoprotein subclasses, the computer readable program code for generating the reports including computer readable program code for generating, for each reported measured subclass value, an adjacently positioned associated risk analysis portion that visually accentuates when there is an increased risk of coronary heart disease associated with the respective lipoprotein subclass measurement to thereby provide a contemporaneous reference guideline for interpretation of the measured lipoprotein subclass value, wherein the computer readable program code means for generating the risk analysis portion presents the LDL particle size value as one of:
• Pattern A corresponding to lower risk, Pattern B corresponding to higher risk, and Pattern AB corresponding to an intermediate risk;
• and wherein said LDL subclass value is identified in said risk analysis portion by visually enhancing the specified pattern associated with the patient-specific LDL subclass value, and wherein the computer readable program code for generating the risk analysis portion includes computer readable program code for presenting each of a plurality of the measured subclass values as a horizontally extending linear bar graph which graphically represents the subclass value relative to a continuum of low to high risk, the continuum of low to high risk being defined according to predefined risk criteria associated with statistical data for the general population.

A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:

• a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising:
• computer readable program code for generating NMR-based lipoprotein measurement values for a patient's blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
• computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
• computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents according to predetermined test criteria to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
• computer program code for evaluating the lipoprotein measurement values and generating a reduced target value or values for what represents an optimal or low risk value for selected lipoprotein constituents to provide a patient-specific treatment guideline based on the presence of predetermined risk criteria;
• and
• computer readable program code for assessing a patient's risk of coronary heart disease based on the presence of at least one of an elevated LDL particleconcentration and/or the metabolic abnormality or atherogenic dyslipidemia.

A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:

• a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising:
• computer readable program code for generating NMR-based lipoprotein measurement values for a patient's blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
• computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
• computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values exist to determine if a clustering of abnormal values exist to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
• computer readable program code for assessing a patient's risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality or atherogenic dyslipidemia;
• and
• computer program code for automatically generating a report of the risk assessment for each patient sample, the computer program code for generating the report including computer program code for:
• (a) arranging each of the obtained lipoprotein subclass constituent values in a viewable format which positions the lipoprotein subclass constituent values as a quantified number adjacent to a corresponding risk analysis portion such that a respective risk analysis portion for each lipoprotein subclass constituent value is positioned in side by side alignment with the corresponding lipoprotein subclass constituent value to act as a contemporaneous guide, the risk analysis portion having a plurality of segments a respective one of which characterizes the quantified lipoprotein subclass constituent value's determined risk level;
• (b) displaying the NMR-measured subclass constituent risk result corresponding to the actual constituent value within the respective risk analysis portion such that the risk associated with the lipoprotein constituent value is readily apparent;
• and
• (c) providing a metabolic abnormality or metabolic syndrome and/or atherogenic dyslipidemia summary identifying whether a clustering of abnormal measured lipoprotein subclass constituent values for selected different lipoprotein subclass constituents exists according to predetermined test criteria and indicating which of the plurality of the measured lipoprotein subclass constituent values are abnormal.

A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:

• a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising:
• computer readable program code for generating NMR-based lipoprotein measurement values for a patient's blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
• computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
• computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
• and
• computer readable program code for assessing a patient's risk of coronary heart disease based on the presence of at least one of an elevated LDL particleconcentration and/or the metabolic abnormality or atherogenic dyslipidemia, wherein the computer program code for assessing a patient's risk of coronary heart disease includes computer program code that identifies the presence of both an elevated LDL particle concentration and the determination of an increased risk for having the metabolic abnormality, metabolic syndrome and/or atherogenic dyslipidemia, and wherein the computer program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents exists to determine the presence of a metabolic abnormality or atherogenic dyslipidemia lack a LDL particle concentration value.

A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:

• a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising:
• computer readable program code for generating NMR-based lipoprotein measurement values for a patient's blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
• computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
• computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values for a plurality of different selected lipoprotein subclass constituents to determine the presence of a metabolic abnormality or atherogenic dyslipidemia;
• computer readable program code for assessing a patient's risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality or atherogenic dyslipidemia;
• and
• computer program code for evaluating the lipoprotein measurement values and generating different values or ranges of values for the predetermined risk criteria that establishes the estimated risk level for at least one selected subclass constituent relative to the general population for a patient-specific treatment guideline based on the presence of predetermined risk criteria.

A computer program product for automatically generating personalized lipoprotein-based assessed risk of coronary heart disease information for a plurality of subjects, the computer program product comprising:

• a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising:
• computer readable program code for generating NMR-based lipoprotein measurement values for a patient's blood plasma or serum sample, the NMR-based lipoprotein measurement values comprising a plurality of lipoprotein constituent values including a constituent value for LDL particle concentration;
• computer readable program code for comparing the LDL particle concentration with predetermined test criteria for determining whether the LDL particle concentration is elevated;
• computer readable program code for comparing a plurality of NMR-based lipoprotein subclass constituent values to predetermined test criteria associated with abnormal lipoprotein values to determine if there is a clustering of abnormal values associated with a plurality of different selected lipoprotein subclass constituents to determine the presence of a metabolic abnormality, metabolic syndrome, and/or atherogenic dyslipidemia;
• computer readable program code for assessing a patient's risk of coronary heart disease based on the presence of at least one of an elevated LDL particle concentration and/or the metabolic abnormality, syndrome and/or atherogenic dyslipidemia;
• and
• computer program code for electronically generating the report and transmitting the report via email to a physician.