Back to results
US 6,576,265 B1Granted
Tissue regenerative composition, method of making, and method of use thereof
AssigneeACell, Inc.
InventorAlan R. Spievack
Life of this patent
Estimating the term…
Abstract
A matrix, including epithelial basement membrane, for inducing repair of mammalian tissue defects and in vitro cell propagation derived from epithelial tissues of a warm-blooded vertebrate.
Claims19
A composition, comprising:
- devitalized mammalian epithelial basement membrane, tunica propria, and tunica muscularis, wherein said basement membrane, tunica propria, and tunica muscularis are delaminated from epithelial cells of a mammalian epithelium.
A composition comprising:
- devitalized mammalian epithelial basement membrane and submucosa, wherein said basement membrane and submucosa are delaminated from the cells of a mammalian epithelium.
A method for manufacture of a devitalized tissue graft composition, comprising:
- deepthelializing a mammalian epithelial tissue to form a devitalized tissue having an epithelial basement membrane;
- and,
- abrading said devitalized tissue on an abluminal surface of said tissue to form a delaminated tissue, wherein the delaminated tissue remaining after abrading said tissue, comprises at least a portion of the epithelial basement membrane and said delaminated tissue comprising said basement membrane induces endogenous tissue restoration.
A matrix for inducing repair of tissue in a mammal, comprising:
- an isolated devitalized mammalian epithelial basement membrane wherein said basement membrane is derived from small intestine, and the tunica propria immediately subjacent to said basement membrane.
A method for inducing repair of diseased, defective or damaged tissue in mammal, said method comprising:
- providing to the defect site, a devitalized matrix comprising a mammalian epithelial basement membrane wherein said matrix induces repair of said tissue when placed in contact with said tissue.
Dependencies are inferred from the claim text.