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US 6,575,956 B1Granted
Methods and apparatus for uniform transcutaneous therapeutic ultrasound
AssigneePharmasonics, Inc.
InventorsAxel F. Brisken, Robert Zuk, John R. McKenzie, Mark W. Cowan
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Abstract
A wide beam ultrasound delivery system providing a uniform exposure field is used to enhance the uptake of injected substances and/or to enhance the transfection of DNA in the tissues of human subject, or reduce the amount of vascular intimal hyperplasia in human subjects following vascular injury.
Claims31
A method of enhancing transfection of DNA delivered into a target region of a patient's body, comprising:
- delivering the DNA into the target region;
- and
- applying a uniform field of ultrasound energy across a wide area of the target region, the ultrasound energy being of a type and an amount sufficient to enhance transfection of the DNA in the target region, wherein the uniform field comprises
- a field which varies in intensity by at least one of (1) less than 10 dB in a lateral direction across the width of the field, and (2) less than 10 dB in an axial direction across the depth of the target region.
1 more element
Dependencies are inferred from the claim text.