Method of treating melanoma
OwnerPatrick Anthony Riley, Andrew Photiou +2inventors
InventorsPatrick Anthony Riley, Andrew Photiou, Tariq Hussain Khan, Helen Mary Osborn
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Abstract
Novel pro-drugs and assay reagents are provided which are useful as therapeutic agents especially for delivery and targetting therapeutically active agents to melanoma cells. The pro-drugs and assay reagents are substrates for tyrosinase and may be represented by the formula TyrX—B—ThrAg*. The compounds of formula TyrX—B—ThrAg* are capable of releasing a therapeutically active agent or assayable substance (ThrAg) at a desired location. TyrX— being a residue of an optionally substituted tyrosine analogue.
Claims8
A method of treating melanoma in a patient comprising administering a compound that is capable of releasing a therapeutically active agent (ThrAg) at a desired location, said compound being a substrate for the tyrosinase enzyme and having the formula:
- TyrX—B—ThrAg*
- wherein TyrX— is a residue of an optionally substituted tyrosine analogue of the structure:
- wherein each Z is independently selected from ═CH—, —C—, ═N—, and ═N+(O−)—;
- and R1 and R2 are independently selected from —H, —Br, —Cl, —I, —F, and —OH;
- wherein B represents a linking group linking TyrX— and ThrAg* selected from:
- and wherein ThrAg* represents a residue of a therapeutically active agent ThrAg.
Dependencies are inferred from the claim text.