Streptococcus pneumoniae antigens and vaccines
AssigneeHuman Genome Sciences, Inc.
InventorsGil H. Choi, Charles A. Kunsch, Steven C. Barash, Patrick J. Dillon, Brian Dougherty, Michael R. Fannon, Craig A. Rosen
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Abstract
The present invention relates to novel vaccines for the prevention or attenuation of infection by Streptococcus pneumoniae. The invention further relates to isolated nucleic acid molecules encoding antigenic polypeptides of Streptococcus pneumoniae. Antigenic polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention additionally relates to diagnostic methods for detecting Streptococcus nucleic acids, polypeptides and antibodies in a biological sample.
Claims21
An isolated polynucleotide consisting of a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 41;
- and
- (b) the complementary strand of (a).
An isolated polynucleotide consisting of at least 50 contiguous nucleotides of a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:41;
- and
- (b) the complementary strand of (a).
An isolated polynucleotide consisting of at least 100 contiguous nucleotides of a nucleic acid sequence selected from the group consisting of:
- (a) SEQ ID NO:
- 41;
- and
- (b) the complementary strand of (a).
Dependencies are inferred from the claim text.