Nucleic acid encoding sodium channels in dorsal root ganglia
AssigneeYale University
InventorsSulayman Dib-Hajj, Stephen G. Waxman
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Abstract
A novel tetrodotoxin resistant sodium channel is described, along with isolated nucleotides that encode this receptor. Methods for identifying agents that modulate the Na+ current through the receptor are provided, as well as related therapeutic and diagnostic methods.
Claims22
An isolated nucleic acid molecule encoding a protein capable of producing a sodium current and comprising at least about eighty (80) percent nucleotide sequence identity to SEQ ID NO:
- 41.
An isolated nucleic acid molecule encoding SEQ ID NO:
- 42.
An isolated nucleic acid molecule comprising nucleotides 628 to 4328 of SEQ ID NO:
- 41.
An isolated nucleic acid molecule of 2 or 1, wherein the nucleic acid molecule encodes a tetrodotoxin-resistant, voltage-gated sodium channel α subunit.
Dependencies are inferred from the claim text.