Generation of therapeutic microfoam
AssigneeBTG International Limited
InventorsTariq Osman, Sheila Bronwen Flynn, David Dakin Iorwerth Wright, Anthony David Harman, Timothy David Boorman
Life of this patent
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Abstract
Improved therapeutic sclerosing microfoams and methods and devices for making them are provided that have advantage in producing a consistent profile injectable foam with minimal input by the physician yet using high volume percentages of blood dispersible gases, thus avoiding use of potentially hazardous amounts of nitrogen.
Claims19
A method for producing a microfoam suitable for use in sclerotherapy of blood vessels said microfoam comprising gas bubbles in which at least 50% by number of the gas bubbles of 25 μm diameter and above are of no more than 200 μm diameter and at least 95% of these gas bubbles are no more than 280 μm diameter, said method comprising passing a mixture of a physiologically acceptable blood dispersible gas capable of being substantially completely dissolved in or absorbed by blood and an aqueous sclerosant liquid through one or more passages having at least one cross-sectional dimension of from 0.1 to 30 μm, the ratio of gas to liquid being controlled such that a microfoam is produced having a density of between 0.07 g/mL to 0.19 g/mL and has a half-life of at least 2 minutes, to produce said microfoam, said microfoam being formed without the prior step of beating with a brush.
A method for producing a microfoam suitable for use in sclerotherapy of blood vessels said microfoam comprising gas bubbles in which at least 50% by number of gas bubbles of 25 μm diameter and above are of no more than 200 μm diameter and at least 95% of these gas bubbles are no more than 280 μm diameter, said method comprising passing a mixture of a physiologically acceptable blood dispersible gas capable of being substantially completely dissolved in or absorbed by blood and an aqueous sclerosant liquid through one or more passages having at least one cross-sectional dimension of from 0.1 to 30 μm, wherein said mixture of gas and sclerosant liquid is not in the form of a microfoam, the ratio of gas to liquid being controlled such that a microfoam is produced having a density of between 0.07 g/mL to 0.19 g/mL and has a half-life of at least 2 minutes, to produce said microfoam.
A method for producing a microfoam suitable for use in sclerotherapy of blood vessels and microfoam comprising gas bubbles in which at least 50% by number of the gas bubbles of 25 mm diameter and above are of no more than 200 mm diameter and at least 95% of these gas bubbles are no more than 280 mm diameter, said method comprising passing a mixture of a physiologically acceptable blood dispersible gas capable of being substantially completely dissolved in or absorbed by blood and an aqueous sclereosant liquid through one or more passages having at least one cross-sectional dimension of from 0.1 to 30 mm, said mixture of gas and sclerosant liquid being in the form of a dispersion of bubbles in liquid or a macrofoam, the ratio of gas to liquid being controlled such that a microfoam is produced having a density of between 0.07 g/mL to 0.19 g/mL and has a half-life of at least 2 minutes, to produce said microfoam.
Dependencies are inferred from the claim text.