Bioengineered vascular graft support prostheses
AssigneesOrganogenesis, Inc., Duke University School of Medicine
InventorsGinger A. Abraham, Robert M. Carr, Jr., Tam Huynh, Otto Per Hagen, Mark Davies
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Abstract
The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
Claims3
A method for producing a collagen tube comprising at least one layer of submucosal collagen of small intestine wherein the method comprises:
- (a) rolling the submucosal collagen around a mandrel and over itself one complete revolution to form a two layer submucosal collagen tube;
- (b) drying the tube on the mandrel;
- (c) contacting the tube with a crosslinking agent to crosslink the collagen;
- (d) removing the crosslinking agent by rinsing the tube;
- (e) drying the crosslinked tube on the mandrel;
- and,
- (f) removing the tube from the mandrel.
A method of using a bioremodelable prosthesis comprising a collagen tube comprising at least one layer of processed tissue matrix of crosslinked submucosal collagen to prevent stretch injury in an autologous vein graft having two ends implanted in the arterial circulation comprising:
- (a) removing a segment of vasculature;
- (b) anastomosizing a first end of the vein graft;
- (c) passing the vein graft through a collagen tube;
- (d) anastomosizing a second end of the vein graft;
- and,
- (e) covering the vein graft and both anastomoses with said collagen tube.
Dependencies are inferred from the claim text.