Multivalent macrolide antibiotics

A compound of the formula:

• L′—X′—L″
• or a pharmaceutically-acceptable salt thereof;
• wherein L′ is selected from the group consisting of:
• L″ is a moiety of formula:
• X′ has the formula:
• —Xa—Z—(Ya—Z)m—Yb—Z—Xa—
• wherein
• m is an integer of from 0 to 20;
• Xa at each separate occurrence is selected from the group consisting of —O—, —S—, —NR—, —C(O)—, —C(O)O—, —C(O)NR—, —C(S), —C(S)O—, —C(S)NR— and a covalent bond where R is as defined below;
• Z is at each separate occurrence is selected from the group consisting of alkylene, substituted alkylene, cycloalkylene, substituted cylcoalkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, cycloalkenylene, substituted cycloalkenylene, arylene, heteroarylene, heterocyclene, and a covalent bond;,
• Ya and Yb at each separate occurrence are selected from the group consisting of —C(O)NR′—, —NR′C(O)—, —NR′C(O)NR′—, —C(═NR′)—NR′—, —NR′C(═NR′)—, —NR′C(O)—O—, —P(O)(OR′)—O—, —S(O)nCR′R″—, —S(O)n—NR′—, —S—S— and a covalent bond;
• where n is 0, 1 or 2;
• and
• R,R′ and R″ at each separate occurrence are selected from the group consisting of hydrogen, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, alkenyl, substituted alkenyl, cycloalkenyl, substituted cycloalkenyl, alkynyl, substituted alkynyl, aryl, heteroaryl and heterocyclic.