Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
AssigneeMcGill University
InventorRima Rozen
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Abstract
The invention features methods for diagnosing subjects at risk for or suffering from a disease or disorder, such as a psychosis. Methods are also provided for selecting a preferred therapy for a particular subject or group of subjects.
Claims13
A method of diagnosing a schizophrenia in a subject, said method comprising the steps of:
- (a) analyzing the methylenetetrahydrofolate reductase (MTHFR) nucleic acid in a sample obtained from said subject;
- and
- (b) determining the presence of a heterozygous C/T mutation at position 677 of MTHFR in said subject, wherein the presence of said mutation is indicative of said subject having said schizophrenia.
A method of determining a risk for a schizophrenia or propensity thereto in a subject, said method comprising the steps of:
- (a) analyzing the MTHFR nucleic acid in a sample obtained from said subject;
- and
- (b) determining the presence of a heterozygous C/T mutation at position 677 of MTHFR in said subject, wherein the presence of said mutation is indicative of a risk for a schizophrenia or propensity thereto in said subject.
A method of diagnosing a schizophrenia in a subject, said method comprising the steps of:
- (a) analyzing the MTHFR nucleic acid in a sample obtained from said subject;
- (b) determining the presence of a heterozygous C/T mutation at position 677 of MTHFR, wherein the presence of said mutation at position 677 is indicative of said subject having said schizophrenia;
- and
- (c) determining the presence of at least one other MTHFR mutation at a position other than 677.
A method of diagnosing a risk for a schizophrenia or propensity thereto in a subject, said method comprising the steps of:
- (a) analyzing the MTHFR nucleic acid in a sample obtained from said subject;
- (b) determining the presence of a heterozygous C/T mutation at position 677 of MTHFR, wherein the presence of said mutation at position 677 is indicative of a risk for a schizophrenia or propensity thereto;
- and
- (c) determining the presence of at least one other MTHFR mutation at a position other than 677.
Dependencies are inferred from the claim text.