Methods of spray drying pharmaceutical compositions
AssigneeInhale Therapeutic Systems
InventorsThomas E. Tarara, Jeffry G. Weers, Alexey Kabalnov, Ernest G. Schutt, Luis A. Dellamary
Life of this patent
Estimating the term…
Abstract
Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the invention is directed to spray drying a feed stock comprising a phospholipid and calcium chloride.
Claims104
A method for forming a powder comprising perforated microstructures for pharmaceutical applications by spray drying comprising the steps of:
- providing a feed stock comprising a bioactive agent, surfactant, and a blowing agent wherein said blowing agent is selected from the group consisting of fluorinated compounds, nonfluorinated oils, ammonium salts, alcohols, chloroform, ethyl acetate, acetone, nitrogen, carbon dioxide, camphor, and latex wherein the ratio of blowing agent/surfactant is between 1.0-60 w/w;
- atomizing said feed stock to produce dispersed droplets;
- drying said droplets to form perforated microstructures comprising said bioactive agent and surfactant;
- and
- collecting said perforated microstructures.
A method for forming a particulate composition for pharmaceutical applications by spray drying comprising:
- providing a feed stock comprising a phospholipid and calcium chloride;
- atomizing said feed stock to produce dispersed droplets;
- drying said droplets in order to form particulates comprising phospholipid and calcium, said particulates comprising a bulk density of less than 0.5 g/cm3;
- and collecting said particulates.
A method for forming a powder comprising perforated microstructures for pharmaceutical applications by spray drying comprising the steps of:
- providing a feed stock comprising a bioactive agent, surfactant, and 2-50% v/v of a blowing agent selected from the group consisting of fluorinated compounds, non-fluorinated oils, ammonium salts, alcohols, chloroform, ethyl acetate, acetone, nitrogen, carbon dioxide, camphor, and latex;
- atomizing said feed stock to produce dispersed droplets;
- and
- drying said droplets to form perforated microstructures comprising said bioactive agent and surfactant.
Dependencies are inferred from the claim text.