US 6,562,836 B1 · Methods and compounds for inhibiting amyloid deposits

Abstract

Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

Claims172

Dependent claims

A method for inhibiting IAPP-associated amyloid deposits in a subject, comprising administering to said subject an effective amount of an IAPP-inhibiting compound, or a pharmaceutically acceptable ester, acid or salt thereof, such that said IAPP-associated amyloid deposits are inhibited, wherein said IAPP-inhibiting compound is of the formula

wherein A1, A2, A3, A4, A5 and A6 are independently alkyl, O, S, or —NH;
n (for each individual A group) is 0 or 1;
m is 1;
l, p and q are independently 0, 1, or 2;
R7, R8, R9, R10, R11, R12, R13, and R14 are independently hydrogen, an anionic group at physiological pH, alkyl, alicyclyl, heterocyclyl or aryl, and adjacent R groups may form an unsubstituted or substituted cyclic or heterocyclic ring.

2 more elements

Dependencies are inferred from the claim text.

Methods and compounds for inhibiting amyloid deposits

Life of this patent

Methods and compounds for inhibiting amyloid deposits

Life of this patent

Abstract

Claims172