2,4-substituted quinoline derivatives

A compound of the formula

• or a pharmaceutically acceptable salt thereof wherein:
• R1 at each occurrence is independently selected from the group consisting of hydrogen, C1-C6 alkyl, halogen, cyano, haloalkyl, haloalkoxy, hydroxy, amino, —NH(C1-C6 alkyl), and —N(C1-C6 alkyl) (C1-C6 alkyl);
• at least one of Ra or Rb is selected from halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, phenyl substituted with from 0 to 3 R6, —XR7, Y, C1-C6 alkyl, —O(C1-C6 alkyl), —NH(C1-C6 alkyl) and —N(C1-C6 alkyl) (C1-C6 alkyl), wherein each C1-C6 alkyl group is independently substituted with from 0 to 2 R6;
• the remaining Ra and Rb at each occurrence are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, C1-C6 alkoxy substituted with 0-2 R6, —NH(C1-C6 alkyl) wherein the C1-C6 alkyl group is substituted with 0-2 R6, —N(C1-C6 alkyl) (C1-C6 alkyl) wherein the C1-C6 alkyl groups are independently substituted with 0-2 R6, C1-C6 alkyl wherein
• the C1-C6 alkyl group is substituted with 0-2 R6, phenyl substituted with 0-3 R6, —XR7, and Y;
• W represents phenyl, thienyl, or pyridyl, wherein each is substituted with Rd, Rd′, and Rd″ which are independently selected from the group consisting of hydrogen, halogen, cyano, nitro, haloalkyl, haloalkoxy, hydroxy, amino, C1-C6 alkyl substituted with 0-2 R6, C1-C6 alkoxy substituted with 0-2 R6, —NH(C1-C6 alkyl) wherein the C1-C6 alkyl is substituted with 0-2 R6, phenyl substituted with 0-3 R6, —XR7, Y, and —N(C1-C6 alkyl1) (C1-C6 alkyl2) wherein alkyl1 and alkyl2 are independently substituted with 0-2 R6, or
• alkyl1, alkyl2 and the nitrogen to which they are attached form a heterocycloalkyl ring substituted with 0-2 R6;
• X at each occurrence is independently selected from the group consisting of —CH2—, —CHR8—, —O—, —S(O)m—, —NH—, —NR8—, —C(O)—, —C(O)O—, —C(O)NH—, —C(O)NR8—, —S(O)mNH—, —S(O)mNR8—, —NHC(O)—, —NR8C(O)—, —NHS(O)m—, and —NR8S(O)m—;
• wherein m is 0, 1, or 2;
• R6 at each occurrence is independently selected from the group consisting of halogen, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, —NH(C1-C6 alkyl), —N(C1-C6 alkyl) (C1-C6 alkyl), —NH—(C1-C6 alkyl-Y), —N(C1-C6 alkyl)—(C1-C6 alkyl-Y), —NH—(C1-C6 alkyl-N(C1-C6 alkyl) (C1-C6 alkyl)), —N(C1-C6 alkyl)—(C1-C6 alkyl N(C1-C6 alkyl) (C1-C6 alkyl)), morpholinyl, pyrrolidinyl, piperidinyl, thiomorpholinyl, piperazinyl, homopiperazinyl, S(O)m(C1-C6 alkyl), haloalkyl, haloalkoxy, —CO(C1-C6 alkyl), —CONH(C1-C6 alkyl), CON(C1-C6 alkyl) (C1-C6 alkyl), —XR7, and Y;
• wherein
• m is 0, 1, or 2;
• R7 and R8 at each occurrence are independently C1-C8 alkyl, wherein R7 and R8 are substituted with 0, 1, 2, 3, or 4 substituents selected from the group consisting of oxo, hydroxy, halogen, amino, cyano, nitro, haloalkyl, haloalkoxy, C1-C6 alkoxy, —NH (C1-C6 alkyl), —N(C1-C6 alkyl) (C1-C6 alkyl), —NHC(O) (C1-C6 alkyl), —N(C1-C6 alkyl)C(O) (C1-C6 alkyl), —NHS(O)m(C1-C6 alkyl), —S(O)m(C1-C6 alkyl), S(O)mNH(C1-C6 alkyl), and —S(O)mN(C1-C6 alkyl) (C1-C6 alkyl), and Y′;
• wherein m is 0, 1, or 2;
• and
• Y and Y′ at each occurrence are independently selected from 5- to 8-membered carbocycles and heterocycles, which are saturated, partially unsaturated, or aromatic, and contain zero, one or two heteroatoms selected from N, O, and S, and which carbocycles and heterocycles may be further substituted with 1, 2, 3, or 4 substituents selected from the group consisting of halogen, oxo, hydroxy, amino, nitro, cyano, C1-C6 alkyl, C1-C6 alkoxy, —NH(C1-C6 alkyl), —N(C1-C6 alkyl) (C1-C6 alkyl), and —S(O)a(C1-C6 alkyl);
• wherein a is 0, 1, or 2.