Method of preparing a tissue sealant-treated biomedical material

A method of preparing a biomedical device intended for implantation into an animal's body and having a supplemented tissue sealant composition applied to at least a portion of at least one surface thereof, said method comprising the steps of:

• (a) preparing a supplemented tissue sealant composition comprising:
• (i) at least one supplement selected from the group consisting of an analgesic, an anesthetic, an antimicrobial compound, an antibody, an anticoagulant, an antifibrinolytic agent, an anti-inflammatory compound, an antiparasitic agent, an antiviral compound, a cytokine, a cytotoxin or cell proliferation inhibiting compound, a chemotherapeutic drug, a hormone, an interferon, a lipid, an oligonucleotide, a polysaccharide, a protease inhibitor, a proteoglycan, a polypeptide, a steroid, a vasoconstrictor, a vasodilator, a vitamin, and a mineral, and
• (ii) fibrinogen, or a derivative or metabolite thereof, in an amount which forms a fibrin matrix;
• and
• (b) applying said supplemented tissue sealant composition of step (a) to at least a portion of at least one surface of said biomedical device under conditions whereby said fibrinogen forms a fibrin matrix which promotes engraftment of said biomedical device to and/or on and/or into the surrounding tissue following implantation of said biomedical device into an animal's body;
• wherein said supplemented tissue sealant composition contains substantially no collagen.