Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
AssigneeNanopass Ltd.
InventorYehoshua Yeshurun
Life of this patent
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Abstract
A device for the transport of fluids through a biological barrier includes a number of microneedles projecting from the front face of a substrate. A conduit is associated with each of the microneedles to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle. Each of the microneedles is configured to provide a penetrating tip, and each conduit terminates at an opening which is proximal with respect to the microneedle tip. Also described are microneedle-based devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.
Claims14
A device for the transport of fluids through a biological barrier, the device comprising:
- (a) a substrate defining a substantially planar front face of the device;
- (b) a plurality of microneedles projecting from said substantially planar front face, each of said microneedles having a maximum width dimension measured parallel to said front face of no more than about 400 μm and a maximum height dimension measured perpendicular to said front face of no more than about 2 mm;
- and
- (c) a conduit associated with each of said microneedles and extending through at least part of said substrate, each of said conduits being configured to provide a fluid flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle,
- wherein each of said microneedles is formed as a conical pyramid having a first conical angle and terminating at an apex, and wherein said conduit is formed as a bore intersecting said conical pyramid not at said apex.
A device for the transport of fluids through a biological barrier, the device comprising:
- (a) a substrate having first and second parallel outward-facing surfaces;
- (b) a plurality of bores extending into said substrate from said first surface, each of said bores being substantially symmetrical about a central bore-axis;
- and
- (c) a plurality of conical projections projecting from said second surface, each of said conical projections being substantially symmetrical about a central cone-axis,
- (d) wherein said bores and said conical projections are configured such that each of said bores intersects an external surface of a corresponding one of said conical projections, said bore-axis and said cone-axis being non-coincident.
A device for the delivery of fluids through a biological barrier, the device comprising:
- (a) a substrate with a plurality of microneedles projecting therefrom, each of said microneedles having a maximum width dimension of no more than about 400 μm and a maximum height dimension of no more than about 2 mm;
- (b) a plurality of hollow elements, each hollow element being deployed substantially concentrically around, and slightly spaced from, a corresponding one of said microneedles so as to define an annular passageway extending between said hollow element and said microneedle along part of the height of said microneedle;
- and
- (c) at least one fluid flow channel associated with said substrate and in fluid communication with each of said annular passageways for supplying fluid to said annular passageways.
Dependencies are inferred from the claim text.