Software for high throughput microfluidic systems
AssigneeCaliper Technologies Corp.
InventorsSteven J. Gallagher, J. Wallace Parce
Life of this patent
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Abstract
Techniques for analyzing an array of compounds utilizing a high throughput microfluidic system are provided. The system can translate a plurality of multiwell plates through various stations for analysis. Effects to sample compounds can be identified according to deviations in a steady state signal. Also, a user can enter the dwell times for sample compounds and a buffer solution so that the system will alternatingly inject the sample compounds and buffer solution into a microfluidic device according to the specified dwell times.
Claims41
A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving a signal corresponding to sample compounds being driven through the microfluidic device;
- analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation, wherein the threshold deviation is 10%;
- and
- identifying a sample compound that caused the threshold deviation.
A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving a signal corresponding to sample compounds being driven through the microfluidic device;
- analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation and wherein the expected signal profile is based on a signal from a control experiment for obtaining the expected signal profile;
- and
- identifying a sample compound that caused the threshold deviation.
A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving a signal corresponding to sample compounds being driven through the microfluidic device, wherein the sample compounds are stored in multiple wells in which markers are stored in known wells;
- analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation;
- and
- identifying a sample compound that caused the threshold deviation.
A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving a signal corresponding to sample compounds being driven through the microfluidic device;
- analyzing the signal to detect a deviation from a steady state signal, wherein analyzing the signal includes determining if the signal exceeds a threshold deviation;
- identifying a sample compound that caused the threshold deviation;
- identifying sample compounds in the signal that are near in time being driven through the microfluidic device to the identified sample compound;
- and
- directing the identified sample compounds to be driven through the microfluidic device again for analysis.
A computer implemented method of analyzing an array of sample compounds utilizing a microfluidic device, comprising:
- receiving user input specifying a dwell time for the sample compounds;
- receiving user input specifying a dwell time for a buffer solution;
- receiving user input specifying at least one of an initial delay time before the sample compounds and buffer solution are injected into the microfluidic device and a final delay time after the sample compounds and buffer solution are injected into the microfluidic device;
- and
- alternatingly injecting the sample compounds and buffer solution into the microfluidic device for the specified dwell times for the sample compounds and buffer solution.
A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
- computer code that receives user input specifying a dwell time for the sample compounds;
- computer code that receives user input specifying a dwell time for a buffer solution;
- computer code that directs the sample compounds and buffer solution to be alternatingly injected into the microfluidic device for the specified dwell times for the sample compounds and buffer solution;
- computer code that receives user input specifying at least one of an initial delay time before the sample compounds and buffer solution are injected into the microfluidic device and a final delay time after the sample compounds and buffer solution are injected into the microfluidic device;
- and
- a computer readable medium that stores the computer codes.
A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
- computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
- computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation, wherein the threshold deviation is 10%;
- computer code that identifies a sample compound that caused the threshold deviation;
- and
- a computer readable medium that stores the computer codes.
A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
- computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
- computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation and wherein the expected signal profile is based on a signal from a control experiment for obtaining the expected signal profile;
- computer code that identifies a sample compound that caused the threshold deviation;
- and
- a computer readable medium that stores the computer codes.
A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
- computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device, wherein the sample compounds are stored in multiple wells in which markers are stored in known wells;
- computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation;
- computer code that identifies a sample compound that caused the threshold deviation;
- and
- a computer readable medium that stores the computer codes.
A computer program product that analyzes an array of sample compounds utilizing a microfluidic device, comprising:
- computer code that receives a signal corresponding to sample compounds being driven through the microfluidic device;
- computer code that analyzes the signal to detect a deviation from a steady state signal, wherein the computer code that analyzes the signal includes computer code that determines if the signal exceeds a threshold deviation;
- computer code that identifies a sample compound that caused the threshold deviation;
- computer code that identifies sample compounds in the signal that are near in time being driven through the microfluidic device to the identified sample compound;
- computer code that directs the identified sample compounds to be driven through the microfluidic device again for analysis;
- and
- a computer readable medium that stores the computer codes.
Dependencies are inferred from the claim text.