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US 6,555,813 B1Granted
Probes with hydrophobic coatings for gas phase ion spectrometers
AssigneeCiphergen Biosystems, Inc.
InventorsJody Beecher, Frank Scheufele, Kamen Voivodov, Scot Weinberger, William Landgraf
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Abstract
This invention provides a mass spectrometry probe including a substrate having a surface and a film that coats the surface. The film includes openings that define features for the presentation of an analyte. The film also has a lower surface tension that the surface tension of the substrate surface, and has a water contact angle between 120° and 180°.
Claims24
A probe that is removably insertable into a laser desorption mass spectrometer comprising:
- a) a substrate having a surface adapted to present an analyte to an ionization source and
- b) a film that coats the surface, wherein the film:
- i) comprises at least one opening that exposes the surface, thereby defining a feature for applying a liquid comprising an analyte;
- ii) has a water contact angle of between 120° and 180°;
- and
- iii) has less surface tension than the substrate surface, whereby a liquid applied to the feature is sequestered in the feature.
3 more elements
Dependencies are inferred from the claim text.