Protein kinase inhibitor
AssigneeCalyx Therapeutics, Inc.
InventorsSubramaniam Sriram, John Bright, Bishwajit Nag, Somesh D. Sharma
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Abstract
A compound of the formula I: wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy, alkoxy of 1-6 carbon atoms —CO2Z, —O(CH2)mCO2Z, —SO3Z, —OPO3Z2; and Y is cyano, —C(NR1R2)═C(CN)2; wherein X═O or S, and R1 and R2 are independently H, benzyl, —CH(CH3)C6H6, —(CH2)n C6H6, phenyl; —CO2R; n=2-4; R is lower alkyl of 1-6 carbon atoms; m=1-4 and Z is H, a cation or lower alkyl of 1-6 cabon atoms; is used for treating inflammation, immunological diseases or diabetes.
Claims10
A compound of the formula:
- wherein A and C are independently alkyl of 1-6 carbon atoms, hydroxy or alkoxy of 1-6 carbon atoms;
- B is —CO2Z,—O(CH2)mCO2Z2, —SO3Z or —OPO3Z, Y is cyano;
- m is 1 to 4 ;
- and Z is H, a cation or alkyl of 1-6 carbon atoms.
A compound of the formula:
- wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy or alkoxy of 1-6 carbon atoms;
- B is —O(CH2)mCO2Z, —SO3Z or —OPO3Z2;
- Y is cyano;
- m is 1-4 and Z is H, a cation or alkyl of 1-6 carbon atoms.
Dependencies are inferred from the claim text.