Back to results
US 6,555,693 B2Granted
Charged compounds comprising a nucleic acid binding moiety and uses therefor
AssigneeGenesoft, Inc.
InventorsYigong Ge, Matthew J. Taylor, Eldon E. Baird, Heinz E. Moser, Roland W. Bürli
Life of this patent
Estimating the term…
Abstract
Charged compounds are provided that comprise one or more regions of localized positive charge, compositions comprising such compounds, methods of synthesizing such compounds, methods of screening such compounds to identify those having anti-infective activity, and methods of using such compounds to prevent or inhibit infections. These compounds, and compositions containing them, have multiple applications, including use in human and animal medicine and in agriculture.
Claims12
A compound of the formula (Ia)
- or a pharmaceutically acceptable salt thereof, wherein
- R5 is a member selected from the group consisting of halogen, OR7 and N(R7)2;
- R6 is a member selected from the group consisting of H, halogen, a substituted or unsubstituted (C1-C12) alkyl group and a substituted or unsubstituted (C1-C12)heteroalkyl group;
- each R7 is independently selected from the group consisting of H, a substituted or unsubstituted (C1-C12) alkyl group and a substituted or unsubstituted (C1-C12)heteroalkyl group;
- each Q is independently (CH2)2, (CH2)3, or a heteroaromatic group other than an N-methylpyrrole group;
- each of a, b, and d is independently 0, 1, 2, 3, 4, or 5, with the proviso that at least one of a, b, or d is other than 0;
- each of c, e and f is independently 0 or 1.
4 more elements
Dependencies are inferred from the claim text.