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US 6,555,687 B1Granted
Chloropyrimidine intermediates
OwnerSusan Mary Daluge, Michael Tolar Martininventors
Life of this patent
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Abstract
The present invention relates to certain novel pyrimidine intermediates and their salts, processes for their preparation and processes for their conversion to 9-substituted-2-aminopurines which are useful in medical therapy.
Claims10
A compound of formula (I)
- wherein R1 and R2, which may be the same or different, are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen.
A compound of formula (II)
- wherein R1 and R2, which may be the same or different, are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen.
2-Amino-4,6-dichloro-5-{(dimethylamino)methyleneamino}pyrimidine.
A compound of formula (Ia)
- wherein R1 and R2, which may be the same or different, are C1-8 alkyl and R3 is —NH2 or
A process for the preparation of a compound of formula (I)
- wherein R1 and R2, which may be the same or different, are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen, comprising reacting 2,5,-diamino-4,6-dihydroxypyrimidine, or a salt thereof, with a compound of formula (V)
- wherein R1 and R2, which may be the same or different, are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen.
A process for the preparation of a compound of formula (II)
- wherein R1 and R2, which may be the same or different, are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen, comprising hydrolysing a compound of formula (I)
- wherein R1 and R2, which may be the same or different are selected from C1-8 alkyl, C3-8 cycloalkyl, and aryl groups optionally substituted by C1-4 alkyl or halogen.
Dependencies are inferred from the claim text.