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US 6,555,684 B2Granted
Pyrimidinyl compounds for treatment of central nervous system disorders
AssigneeTargacept, Inc.
InventorsWilliam Scott Caldwell, Gary Maurice Dull, Grayland Page Dobson
Life of this patent
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Abstract
Patients susceptible to or suffering from central nervous system disorders are treated by administering effective amounts of aryl substituted aliphatic amine compounds, aryl substituted olefinic amine compounds or aryl substituted acetylenic amine compounds. A representative compound is (E)-N-methyl-5-(3-pyridinyl)-4-penten-2-amine.
Claims7
A compound having the formula:
- wherein n is 2, 3, 4, 5, 6, or 7;
- Z′ and Z″ individually represent hydrogen or lower alkyl containing one to five carbon atoms;
- at least one of Z′ or Z″ is lower alkyl;
- A, A′ and A″ individually represent hydrogen, alkyl containing one to seven carbon atoms or halo;
- the wavy line in the structure represents a cis (Z) or trans(E) form of the compound;
- E′ and E″ individually represent hydrogen, lower alkyl containing one to five carbon atoms or halo-substituted lower alkyl containing one to five carbon atoms;
- and at least one of E′ or E″ represents lower alkyl.
4 more elements
Dependencies are inferred from the claim text.