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US 6,555,679 B2Granted
Method for preparation of ceftiofur sodium from its hydrohalide salts
AssigneeOrchid Chemicals & Pharmaceuticals Limited
InventorsPandurang Balwant Deshpande, Bhausaheb Pandarinath Khadangale
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Abstract
The present invention relates to a process for preparing sodium salt of cephalosporins from their corresponding hydrohalide salt, which is neutralized with trimethylsilylating agent for the first time.
Claims9
A process for preparing a ceftiofur sodium of formula (II)
- said process comprising:
- (a) dissolving and neutralizing the hydrohalide salt of ceftiofur acid using a silylating agent in an aprotic organic solvent and precipitation of a ceftiofur acid, and
- (b) dissolving the ceftiofur acid from step (a) in a solvent and reacting same with a sodium exchanging reagent dissolved in a suitable solvent and precipitating ceftiofur sodium therefrom.
Dependencies are inferred from the claim text.