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US 6,555,676 B2Granted
Biologically active phosphotriester-type compounds
AssigneeCentre National De La Recherche Scientifique
InventorsGilles Gosselin, Jean-Louis Imbach, Christian Perigaud
Life of this patent
Estimating the term…
Abstract
Compounds of formula RS—P(═O)(QR)—Nu where: R is a radical —(CH2)n—W—X; X is a radical —C(═Z)(Y) or —S—U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted with, for example, an OH, SH or NH group; n is equal to 1 to 4, preferably 1 or 2; and Nu is a radical consisting of a residue of a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.
Claims9
A compound having formula Ia:
- RS—P(═O)(QR)—Nu (Ia)
- in which:
- each R is, independently, —(CH2), —W—X;
- X is —C(═Z)(Y) or —S—U;
- Z is O or S;
- W is O or S;
- Q is O or S;
- each of Y and U is, independently, an alkyl, aryl or saccharide radical;
- n is 1 to 4;
- and
- Nu is a nucleoside in the form of its D enantiomer.
8 more elements
A compound having formula Ia:
- RS—P(═O)(QR)—Nu (Ia)
- in which:
- each R is, independently, —(CH2)n—W—X;
- X is —C(═Z)(Y) or —S—U;
- Z is O or S;
- W is O or S;
- Q is O or S;
- each of Y and U is, independently, an alkyl, aryl or saccharide radical;
- n is 1 to 4;
- and
- Nu is a nucleoside in the form of its L enantiomer.
8 more elements
Dependencies are inferred from the claim text.