Covalent modification of abnormal prion protein
AssigneeAlbany Medical College
InventorMark D. Scott
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Abstract
A prion-physiological structure and associated method of formation. A provided abnormal prion has a transforming power over a normal prion to convert the abnornal prion into defective prion that mimics the abnormal prion. A linker molecule is then bonded to the abnormal prion, wherein a polymer that is covalently attached to the linker molecule facilitates formation of a polymerized abnormal prion that does not have the transforming power over the normal prion.
Claims22
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein the polymer has a long chain length that inactivates the transforming power.
A method for forming a prion-physiological structure, comprising:
- providing an abnormal prion that has a transforming power over a normal prion;
- and
- covalently bonding a linker molecule to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein a camouflaging by the polymer of a charge site at the abnormal prion inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion that does not have the transforming power over the normal prion.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein the polymer has a long chain length that inactivates the transforming power.
A prion-physiological structure, comprising:
- an abnormal prion that has a transforming power over a normal prion;
- and
- a linker molecule covalently bonded to the abnormal prion, wherein a polymer is covalently attached to the linker molecule to form a polymerized abnormal prion, and wherein a camouflaging by the polymer of a charge site at the abnormal prion inactivates the transforming power.
Dependencies are inferred from the claim text.