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US 6,555,650 B1Granted
Cyclic analogs of histatins
OwnerGilles Andre Lajoie, Dyanne Brewerinventors
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Abstract
Cyclic analogues of histatin H-5, having from about 7-20 amino acid units exhibiting substantial homology to histatin H-5, and having a cyclic portion of from 5-16 of the amino acid units, have been found to exhibit enhanced bio-activity against a variety of different microorganisms. The cyclic structure is imparted by replacement of naturally occurring amino acids in histatin-5 sequences by, for example, by cysteine units, so as to cause cyclization through formation of disulfide bridges.
Claims17
A synthetic peptide:
- having 15 to 20 amino acid units including a 15 amino acid region which is at least 78% homologous in amino acid sequence to a 15 amino acid portion of SEQ ID NO:1;
- between 8 to 12 of said 15 to 20 amino acid units forming a cyclic structure;
- said cyclic structure including a Glu Lys pair;
- said Glu Lys pair consisting of a glutamic acid residue and a lysine residue;
- said glutamic acid residue located immediately adjacent and on the amino side of a lysine residue;
- said peptide further having at least three amino acid units on both sides of said Glu Lys pair;
- said cyclic structure having at least a first and second point of cyclization, with said first point of cyclization being distinct from and located on one side of said Glu Lys pair and said second point of cyclization being distinct from and located on another side of said Glu Lys pair;
- each said point of cyclization being an amino acid having a side chain adapted to form a link with the amino acid side chain of the other point of cyclization;
- said points of cyclization being adapted to interact to form said cyclic structure;
- said points of cyclization being selected from lysine, glutamic acid and cysteine;
- said first point of cyclization being lysine when said second point of cyclization is glutamic acid;
- and
- said first point of cyclization being cysteine when said second point of cyclization is cysteine.
10 more elements
Dependencies are inferred from the claim text.