Latent reactive blood compatible agents
AssigneeSurModics, Inc.
InventorsPatrick E. Guire, Aron B. Anderson, Richard A. Amos, Terrence P. Everson
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Abstract
A reagent and related method for use in passivating a biomaterial surface, the reagent including a latent reactive group and a bifunctional aliphatic acid (e.g., fatty acid), in combination with a spacer group linking the latent reactive group to the aliphatic acid in a manner that preserves the desired function of each group. Once bound to the surface, via the latent reactive group, the reagent presents the aliphatic acid to the physiological environment, in vivo, in a manner (e.g., concentration and orientation) sufficient to hold and orient albumin.
Claims10
A method of preparing a passivating biomaterial surface, the method comprising the steps of coating a biomaterial surface with a reagent comprising a latent reactive group and a bifunctional aliphatic acid, both groups being covalently attached to a spacer in a manner that permits the latent reactive group to be activated in order to attach the reagent to the surface, and that permits the aliphatic acid of the attached reagent to attract and bind a proteinaceous moiety in order to passivate the surface and activating the latent reactive group(s) under conditions suitable to covalently bond the reagent to the surface.
Dependencies are inferred from the claim text.