US 6,555,584 B1Granted

Acylsulfonamide derivative

AssigneeAjinomoto Co., Inc.

InventorsHiroshi Ikawa, Masato Nishimura, Keiji Okada, Takashi Nakamura

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Abstract

This invention provides a novel acylsulfonamide derivative which can be used as an ACC activity inhibitor effective for the treatment of visceral fat syndrome that becomes the risk-factor of diseases of adult people such as myocardial infarction, cerebral infarction and diabetes. Particularly, it relates to an acylsulfonamide derivative represented by a general formula 1 wherein R1 is substituted/unsubstituted C2-C12 alkyl or alkoxy group or substituted/unsubstituted C2-C12 alkenyl or alkynyl group, R2 is hydrogen atom, hydroxyl group, mercapto group, substituted/unsubstituted C1-C6 alkoxy or alkylthio group, nitro group, halogen atom, trichloromethyl group, trifluoromethyl group or cyano group, R3 is substituted/unsubstituted C1-C20 alkyl or alkoxy group, substituted/unsubstituted C2-C20 alkenyl or alkynyl group, substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group, substituted amino group, substituted/unsubstituted C2-C20 alkenyloxy or alkynyloxy group or R4O— (wherein R4 is substituted/unsubstituted aromatic hydrocarbon or aromatic heterocyclic group), Y is —CH═CH—, —N═CH—, —CH═N—, sulfur or oxygen, and ring A is aromatic hydrocarbon, aromatic heterocyclic ring or cyclic alkyl group.

Claims5

Dependent claims

An acylsulfonamide derivative represented by a general formula (I)

wherein
R1 represents a substituted or unsubstituted C1-C12 alkyl group, a substituted or unsubstituted C2-C12 alkenyl group, a substituted or unsubstituted C2-C12 alkynyl group or a substituted or unsubstituted C1-C12 alkoxy group,
R2 represents a hydrogen atom, a hydroxyl group, a mercapto group, a substituted or unsubstituted C1-C6 alkoxy group, a substituted or unsubstituted C1-C6 alkylthio group, a nitro group, a halogen atom, a trichloromethyl group, a trifluoromethyl group or a cyano group,
R3 represents a substituted or unsubstituted C1-C20 alkyl group, a substitute or unsubstituted C2-C20 alkenyl group, a substituted or unsubstituted C2-C20 alkynyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, a substituted amino group, a substituted or unsubstituted C1-C20 alkoxy group, a substituted or unsubstituted C2-C20 alkenyloxy group, a substituted or unsubstituted C2-C20 alkynyloxy group or a group represented by R4O— (wherein R4 represents a substituted or unsubstituted aromatic hydrocarbon group or a substituted or unsubstituted aromatic heterocyclic group),
Y is a group represented by —CH=CH—,
ring A is an aromatic hydrocarbon group, to which the acylsulfonamide side chain and the amide side chain are bonded at the 1,2-positions.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application: 09/606,191Filed 29 Jun 2000
Granted: 29 Apr 2003
Term ends: Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07C 311/58
Having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings: having nitrogen atoms of the sulfonylurea…
C07C 311/51
Compounds containing any of the groups [IMAGE cpc-sch-C07C-0977.gif], X being a hetero atom, Y being any atom: y being a hydrogen or a carbon atom
C07C 311/53
Y being a hetero atom: x and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
C07C 2601/14
With a six-membered ring: the ring being saturated