Amino- and amido-diphenyl ethers

Compounds of the general formula (I)

• in which
• R1 represents nitro, amino, acetamido or represents a group of the formula —NH—CO—CO—A or —NH—CH2—CO—A, in which
• A represents hydroxyl or (C1-C4)-alkoxy,
• R2 and R3 are identical or different and denote halogen, C1-C4-alkyl or trifluoromethyl,
• R4 represents a group of the formula
• in which
• E represents straight-chain or branched (C1-C4)-alkyl,
• R6 and R7 are identical or different and, independently of one another, represent straight-chain or branched (C1-C10)-alkyl which can be substituted one or more times, identically or differently, by (C3-C8)-cycloalkyl, (C1-C6)-alkoxy, amino, mono- or di-(C1-C6)-alkylamino, (C1-C4-alkoxycarbonylamino, aminocarbonyl, (C1-C6)-alkoxycarbonyl, or by (C6-C10)-aryl, where aryl is optionally substituted one or more times, identically or differently, by (C1-C4)-alkyl, aminocarbonyl, (C1-C4)-alkanoylamino or halogen, or
• represent (C6-C10)-aryl or (C3-C8)-cycloalkyl, each of which can be substituted by (C1-C4)-alkoxy,
• R8 represents straight-chain or branched (C1-C10)-alkyl which can be substituted by (C3-C8)-cycloalkyl, phenyl or phenoxy, or represents (C3-C8)-cycloalkyl, (C6-C10)-aryl, biphenylyl or (C1-C6)-alkoxy,
• R9 represents straight-chain or branched (C1-C8)-alkyl whose carbon chain can be interrupted by —O— and which can be substituted by (C3-C8)-cycloalkyl or phenyl, or represents (C3-C8)-cycloalkyl, (C2-C6)-alkenyl, or phenyl,
• where the aromatic ring systems mentioned both in R8 and in can, in each case independently of one another, in turn be substituted by trifluoromethyl, halogen, (C1-C4)-alkoxy, (C1-C4)-alkyl or amino,
• R10 represents straight-chain or branched (C1-C15)-alkyl which can be substituted by (C3-Cg)-cycloalkyl, (C1-C4)-alkoxy, phenyl, phenoxy or benzyloxy, where the said aromatic radicals can in turn each be substituted up to three times, identically or differently, by halogen, (C1-C6)-alkyl or (C1-C4)-alkoxy,
• represents (C3-C8)-cycloalkyl which can be substituted by (C1-C4)-alkoxy or phenyl,
• represents (C6-C10)-aryl which can be substituted up to three times, identically or differently, by (C1-C6)-alkyl, (C1-C6)-alkoxy, halogen, cyano, amino, trifluoromethyl or phenyl, or
• denotes a group of the formula —OR13 or NR14R15, in which
• R13 represents straight-chain or branched (C1-C6)-alkyl, and
• R14 and R15 are identical or different and, independently of one another,
• represent hydrogen, straight-chain or branched (C1-C12)-alkyl, which can be substituted by aminocarbonyl, a group of the formula —NR16R17, or can be substituted by phenyl, where phenyl is optionally substituted up to twice, identically or differently, by halogen, (C1-C4)-alkyl, trifluoromethyl or (C1-C4)-alkoxy,
• represent (C3-C8)-cycloalkyl which can be substituted by (C1-C4)-alkyl, or
• represent (C6-C10)-aryl which can be substituted up to three times, identically or differently, by halogen, (C1-C4)-alkyl, trifluoromethyl, (C1-C4)-alkoxy, amino, phenyl or phenoxy, where
• R16 and R17 are identical or different and, independently of one another, represent hydrogen, (C1-C6)-alkyl, phenyl or arylsulphonyl,
• R11 and R12 are identical or different and, independently of one another,
• represent hydrogen, straight-chain or branched (C1-C6)-alkyl, which can be substituted one or more times, identically or differently, by mono-(C1-)-alkylamino, di-(C1-C6)-alkylamino, (C1-C4)-alkoxy, (C1-6)-alkoxycarbonyl, carboxyl, or (C6-C10)-aryl, where the latter in turn is optionally substituted by halogen, trifluoromethyl, (C1-C6)-alkyl or (C1-C6)-alkoxy,
• represent (C3-C8)-cycloalkyl where cycloalkyl is optionally substituted by (C1-C4)-alkyl,
• R5 denotes hydrogen, (C1-C4)-alkyl or (C1-C4)-alkanoyl, and the respective salts and hydrates thereof.