Compounds, their preparation and use

A compound of formula (I)

• wherein
• A is aryl, wherein A is optionally substituted with one or more substituents selected from hydroxy, halogen, perhalomethyl, perhalomethoxy, acyl, cyano, amino, C1-6-alkylamino, C1-6-dialkylamino, methylenedioxy, aralkenyl, aralkynyl, heteroaryloxy, heteroaralkoxy, aralkyl, heteroaralkyl, arylamino, or
• A is optionally substituted with C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl each of which is optionally substituted with one or more substituents selected from C1-6-alkoxycarbonyl or carboxy, or
• A is optionally substituted with C1-6-alkoxy, C1-6-alkylthio or C2-6-alkenyloxy each of which is optionally substituted with one or more halogens, or
• A is optionally substituted with aryloxy, arylthio or aralkoxy each of which is optionally substituted with one or more substituents selected from C1-6-alkoxy, nitro, carboxy or C1-6-alkoxycarbonyl;
• and
• X1 and X2 independently are hydrogen, aryl or heteroaryl each of which is optionally substituted with one or more substituents selected from hydroxy, aryloxy, arylthio, aralkoxy, heteroaryloxy, aralkoxy, C1-6-alkoxy, C1-6-alkylthio, halogen, perhalomethyl, perhalomethoxy, acyl, aryl, heteroaryl, aralkyl, heteroaralkyl, cyano, amino, C1-6-alkylamino, C1-6-dialkylamino, arylamino or methylenedioxy, or aryl or heteroaryl each of which is optionally substituted with one or more substituents selected from C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl each of which is optionally substituted with hydroxy;
• or
• Y is hydrogen, or Y is C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, C4-12-alkenynyl, aralkyl or heteroaralkyl, each of which is optionally substituted with one or more substituents selected from halogen, C1-6-alkyl, perhalomethyl, hydroxy, aryl, heteroaryl, carboxy or amino;
• and
• Z is hydrogen, halogen, hydroxy, or Z is C1-6-alkyl or C1-6-alkoxy, each of which is optionally substituted with one or more substituents selected from halogen, hydroxy, carboxy, amino, cyano or C1-6-alkoxy;
• and
• Q is O, S or NR6, wherein R6 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl, aralkyl, heteroaralkyl and wherein R6 is optionally substituted with one or more substituents selected from halogen, hydroxy, C1-6-alkoxy, amino or carboxy;
• and
• Ar is arylene, which can be optionally substituted with one or more substituents selected from C1-6-alkyl, aryl or C1-6-alkoxy each of which can be optionally substituted with halogen, hydroxy, carboxy, cyano or-heterocyclyl;
• and
• R1 is hydrogen, hydroxy or halogen;
• or R1 forms a bond together with R2;
• and
• R2 is hydrogen or C1-6-alkyl;
• or R2 forms a bond together with R1;
• and
• R3 is hydrogen, or R3 is C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl, aryl, aralkyl, C1-6-alkoxyC1-6alkyl, acyl, heterocyclyl, heteroaryl or heteroaralkyl each of which is optionally substituted with one or more substituents selected from halogen, perhalomethyl, hydroxy or cyano;
• and
• R4 is hydrogen, C1-6-alkyl, C2-6-alkenyl, C2-6-alkynyl, C4-6-alkenynyl or aryl;
• and
• n is an integer ranging from 0 to 3;
• and
• m is an integer ranging from 0 to 1;
• or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate thereof, or any tautomeric forms, stereoisomers, mixture of stereoisomers including a racemic mixture, or polymorphs,
• provided that when m and n are both 0, X1, X2, Y, Z, R1, R2, R3 and R4 do not all represent H.