Use of γ-tocopherol and its oxidative metabolite LLU-α in the treatment of disease
AssigneeLoma Linda University Medical Center
InventorWilliam J. Wechter
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Abstract
The present invention is generally related to the discovery of the therapeutic benefit of administering γ-tocopherol and γ-tocopherol derivatives. More specifically, the use of γ-tocopherol and racemic LLU-α, (S)-LLU-α, or γ-tocopherol derivatives as antioxidants and nitrogen oxide scavengers which treat and prevent high blood pressure, thromboembolic disease, cardiovascular disease, cancer, natriuretic disease, the formation of neuropathological lesions, and a reduced immune system response are disclosed.
Claims3
A method of preventing or treating a disease caused by oxidation in vivo by administering a pharmacologically effective amount of at least one compound selected from the group consisting of:
- (1) 2,5,7,8-tetramethyl-2-(β-carboxyethyl)-6-hydroxychromane, a pharmacologically acceptable salt thereof or a pharmacologically acceptable hydrate thereof and (2) 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxychromane, a pharmacologically acceptable salt thereof or a pharmacologically acceptable hydrate thereof.
Dependencies are inferred from the claim text.