4-oxybenzopyran derivative

A 4-oxybenzopyran derivative of the formula (I)

• wherein,
• R1 and R2 represent each independently a hydrogen atom;
• a C1-6 alkyl group in which said alkyl group may be optionally substituted with a halogen atom, a C1-6 alkoxy group or a hydroxyl group;
• of a phenyl group in which said phenyl group may be optionally substituted with a halogen atom, a hydroxyl group, a nitro group, a cyano group, a C1-6 alkyl group or a C1-6 alkoxy group;
• R3 represents a hydroxyl group or a C1-6 alkylcarbonyloxy group;
• R4 represents a hydrogen atom, a C3-6 cycloalkyl group, a C1-6 alkyl group, a C1-6 akylcarbonyl group, a C1-6 alkylaminocarbonyl group or a di-C1-6 alkylaminocarbonyl group in which said C1-6 alkyl group, said C1-6 alkylcarbonyl group, said C1-6 alkylaminocarbonyl group and said di-C1-6 alkylaminocarbonyl group may be each optionally substituted with a halogen atom, a C1-6 alkoxy group, a C1-6 alkoxy group substituted by a halogen atom;
• a carboxyl group, a C1-6 alkoxycarbonyl group, a hydroxyl group, or an aryl group or a heteroaryl group, in which said aryl group and said heteroaryl group may be optionally substituted with (R9)r, in which R9 represents a halogen atom, a hydroxyl group, a C1-6 alkyl group, a C1-6 alkyl group substituted by a halogen atom or a C1-6 alkoxy group;
• a C1-6 alkoxy group, a C1-6 alkoxy group substituted by a halogen atom;
• or R9 represents a nitro group, a cyano group, a formyl group, a formamide group, an amino group, a C1-6 alkylamino group, a di-C1-6 alkylamino group, a C1-6 alkylcarbonylamino group, A C1-6 alkylsulfonylamino group, an aminocarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, a C1≢alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminosulfonyl group, a C1-6 alkylsulfonyl group, a carboxyl group or an arylcarbonyl group, r represents an integer of 1-3 and each R9 may same or different if r represents 2 or 3;
• or R4 represents an aryl group or a heteroaryl group in which said aryl group and said heteroaryl group may be optionally substituted with (R10)q in which R10 has the same meaning as R9, q represents an integer of 1-3, and each R10 may be same or different if q represents 2 or 3;
• n represents an integer of 0-4;
• X represents —C(═O)NR7—, —NR8—, —NHC(═O)NH— or —S(O)2NH— (in which R7 and R8 represent each independently a hydrogen atom or a C1-6 alkyl group);
• R5 represents a hydrogen atom;
• or a group of the formula:
• in which R12 represents a hydrogen atom;
• a halogen atom;
• a C1-6 alkyl group in which the alkyl group may be optionally substituted with a halogen atom or a C1-6 alkoxy group;
• a C1-6 alkoxy group in which said alkoxy group may be optionally substituted with a halogen atom;
• a phenyl group in which said phenyl group may be optionally substituted with a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group or R12 represents a hydroxyl group, a nitro group, a cyano group, a formyl group, a formamide group, an amino group, a C1-6 alkylamino group, a di-C1-6 alkylamino group, a C1-6 alkylcarbonylamino group, a C1-6 alkylsulfonylamino group, an aminocarbonyl group, a C1-6 alkylaminocarbonyl group, a di-C1-6 alkylaminocarbonyl group, a C1-6 alkylcarbonyl group, a C1-6 alkoxycarbonyl group, an aminosulfonyl group, a C1-6 alkylsulfonyl group, a carboxyl group or an arylcarbonyl group, m represents an integer of 1-3, and each R12 may be same or different if m represents 2 or 3, and R13 represents a hydrogen atom or a C1-6 alkyl group;
• and
• R6 represents a hydrogen atom, a halogen atom, a nitro group or a cyano group;
• or a pharmaceutically acceptable salt thereof.