Apoptosis inhibitor
AssigneeTakeda Chemical Industries, Ltd.
InventorsJunji Matsui, Naoki Tarui, Yu Momose, Ken-ichi Naruo
Life of this patent
Estimating the term…
Loading patent…
AssigneeTakeda Chemical Industries, Ltd.
InventorsJunji Matsui, Naoki Tarui, Yu Momose, Ken-ichi Naruo
Estimating the term…
An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.
A method for inhibiting apoptosis in a mammal comprising administering to said mammal an effective amount of 5-(2,4-dioxothiazolidin-5-ylmethyl)-2-methoxy-N-[4-(trifluoromethyl)benzyl]benzamide, or a pharmaceutically acceptable salt thereof.
A method for treating or preventing disease mediated by promotion of apoptosis, in a mammal in need thereof, comprising administering to said mammal an effective amount of 5-(2,4-dioxothiazolidin-5-ylmethyl)-2-methoxy-N-[4-(trifluoromethyl)benzyl]benzamide, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.