Back to results
US 6,555,551 B1Granted
Stable formulations of ACE inhibitors, and methods for preparation thereof
AssigneeMutual Pharmaceutical Company, Inc.
InventorSpiridon Spireas
Life of this patent
Estimating the term…
Abstract
The present invention provides stable formulations of ACE inhibitors, especially enalapril maleate, that can be manufactured in a time efficient, cost effective manner. Such formulations can be prepared simply and on a large industrial scale. The present invention also provides methods for the preparation of stable formulations of ACE inhibitors, especially enalapril maleate.
Claims3
A method of preparing a stable formulation of ACE inhibitor which comprises the steps of:
- mixing an ACE inhibitor with an alcohol to form an alcoholic dispersion;
- dispersing or dissolving a metal compound in water to form a metal compound dispersion or solution;
- mixing the alcoholic dispersion and the metal compound dispersion until a clear solution is attained;
- adding at least one excipient to the clear solution;
- blending the excipient and the clear solution to form a granulate;
- drying the granulate;
- and
- adding a lubricant to the dried granulate wherein the lubricant is selected from the group consisting of stearates, hydrogenated vegetable oils, and talc.
5 more elements
Dependencies are inferred from the claim text.