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US 6,555,549 B2Granted
Benzo[C] quinolizine derivatives, their preparation and use as 5α-reductases inhibitors
AssigneeApplied Research Systems ARS Holding N.V.
InventorsAntonio Guarna, Mario Serio
Life of this patent
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Abstract
The present invention refers to benzo[c]quinolizine derivatives of general formula (I) their pharmaceutically acceptable salts or esters, processes for their preparation and pharmaceutical compositions containing them.
Claims8
A benzo[c]quinolizine compound selected from the group consisting of:
- 1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 8-chloro-1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 8-methyl-1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 4-methyl-1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 1-methyl-1,2,4,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 4,4a,5,6, tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 8-chloro-4,4a,5,6-tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 8-chloro-1-methyl-4,4a,5,6-tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 8-methyl-4,4a,5,6-tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 4-methyl-4,4a,5,6-tetrahydro-(11H)-benzo[c]quinolizine-3-one (cis) and (trans)
- 8-chloro-4-methyl-1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 4,8-dimethyl-1,2,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one;
- 4,8-dimethyl-4,4a,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one (cis) and (trans);
- and
- 8-chloro-4-methyl-4,4a,5,6 tetrahydro-(11H)-benzo[c]quinolizine-3-one (cis) and (trans).
12 more elements
Dependencies are inferred from the claim text.