Substituted phenyl compounds with immunosuppressing activity and pharmaceutical compositions

A compound of formula

• wherein:
• each R1 independently represents a hydrogen or halogen atom, or a trifluoromethyl, cyano, nitro, C1-C6 alkyl or C1-C6 alkoxy group;
• T represents a group NH;
• U represents an oxygen or sulphur atom or a group NH;
• Ar represents a group
• X represents a bond, an oxygen atom or a group CO, CH2, CH2O O(CH2)m, CH2OCH2, NR5, CH2NR5, NR5CH2, CH2NR5CH2, CONR5, S(O)n or SO2NR5;
• m is 1, 2 or 3;
• n is 0, 1 or 2;
• one of R2 and R3 represents a halogen, cyano, nitro, amino, hydroxyl, or a group selected from
• (i) C1-C6 alkyl optionally substituted by at least one C3-C6 cycloalkyl,
• (ii) C3-C8 cycloalkyl,
• (iii) C1-C6 alkyloxy optionally substituted by at least one C3-C6 cycloalkyl,
• (iv) C3-C8 cycloalkyloxy,
• (v) S(O)pC1-C6 alkyl, or
• (vi) S(O)qC3-C8 cycloalkyl,
• each of these groups being optionally substituted by one or more fluorine atoms, and the other of R2 and R3 represents a hydrogen or halogen atom or a methyl group;
• p is 0, 1 or 2;
• q is 0, 1 or 2;
• R4 represents a 3- to 9-membered saturated heterocyclic ring system containing one or two nitrogen atoms, the heterocyclic ring system being optionally substituted by one or more substitutents independently selected from fluorine atoms, hydroxyl, C1-C6 alkyl, acetyl, hydroxyC1-C6 alkyl, —NR6R7, —(CH2)rNR6R7, —CONR6R7 and pyrimidinyl;
• r is 1, 2, 3, 4, 5 or 6;
• R5 represents a hydrogen atom or a C1-C6 alkyl or C3-C8 cycloalkyl group;
• and
• R6 and R7 each independently represent a hydrogen atom or a C1-C6 alkyl or C3-C8 cycloalkyl group, or R6 and R7 together with the nitrogen atom to which they are attached to form a 3- to 8-membered saturated heterocyclic ring, provided that when R3 represents a cyano group, then X is other than a bond;
• or a pharmaceutically acceptable salt or solvate thereof.