5-arylsulfonyl-imidazo[1′,2′:1,6]pyrido[2,3-b]pyrazine-6-amines and related compounds
AssigneePfizer Inc.
InventorEdward F. Kleinman
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Abstract
This application is directed to a compound of Formula I wherein a, X, R1, R2, R3 and R4 are as defined herein, useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation, inflammatory and central nervous system disorders such as asthma, chronic obstructive pulmonary disease, adult respiratory diseases syndrome, shock, fibrosis, pulmonary hypersensitivity, allergic rhinitis, atopic dermatitis, psoriasis, weight control, rheumatoid arthritis, cachexia, Crohn's disease, ulcerative colitis, arthritic conditions and other inflammatory diseases, depression, multi-infarct dementia and AIDS.
Claims10
A compound of the formula
- or a pharmaceutically acceptable salt thereof;
- wherein
- a is 1, 2, 3 or 4;
- X is N;
- R1 and R2 are each independently selected from hydrogen, (C1-C6)alkyl, cyano, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C3-C7)cycloalkyl, (C6-C10)aryl;
- R3 and R4 are each independently selected from hydrogen, halo, (C1-C6)alkyl, (C1-C6)alkoxy, cyano, hydroxy, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C6-C10)aryl;
- or R1 and R2 may be taken together with the carbons to which they are attached to form a compound of formula II
- wherein
- a, X, R3 and R4 are as defined above;
- X is CH or N;
- b is 1, 2, 3 or 4;
- and
- R5 is hydrogen, halo, (C1-C6)alkyl, (C1-C6)alkoxy, cyano, hydroxy, amino, (C1-C6)alkylamino, ((C1-C6)alkyl)2amino, (C3-C7)cycloalkyl, (C3-C7)cycloalkoxy, (C6-C10)aryl.
Dependencies are inferred from the claim text.