US 6,555,529 B1 · Remedies for intramedullary diseases

Abstract

The present invention has the objective of offering drug for treating abnormalities in bone marrow which corrects the biological balance in the bone marrow, in particular which has the effect of suppressing inflammatory cell infiltration and suppressing cell growth-differentiation factor increase. The present invention relates to drug for treating abnormalities in bone marrow which has, as an effective component, a methanebisphosphonic acid derivative, ester thereof, medicinally acceptable salt thereof, or a hydrate of these. The methanebisphosphonic acid derivatives of the present invention show an outstanding bone marrow abnormality therapeutic effect, so efficacy can be expected in the prevention and treatment of rheumatoid arthritis, multiple myeloma, osteomyelitis and other bone marrow abnormalities. Furthermore, application can also be expected in the prevention and treatment of hypoplastic anaemia, myelocytic leukaemia and other such haematopoietic disorders.

Claims5

Dependent claims

A method of treating patients with bone marrow abnormalities, comprising the step of:

administering an effective amount of a methanebisphosphonic acid derivative represented by formula (Ia),
wherein, in formula (Ia),
B represents —X—(CH2)n—;
n is an integer in the range of 0 to 6;
X represents S, O, or NH;
Y represents a substituted or unsubstituted straight chain or branched chain lower alkyl, comprising 1 to 6 carbon atoms, wherein the substituents are amino, lower alkylamino, di-lower alkylamino or tri-lower alkylsiloxy, or substituted or unsubstituted phenyl, wherein the substituents are lower alkyl, lower alkoxy, lower alkylthio, trifluoromethyl, or halogen;
Z denotes a lower alkyl group, trifluoromethyl group, lower alkenyl, lower alkoxy, lower alkylthio or C3-8 cycloalkyl;
and
m is an integer in the range of 0 to 2.

6 more elements

Dependencies are inferred from the claim text.

Remedies for intramedullary diseases

Life of this patent

Remedies for intramedullary diseases

Life of this patent

Abstract

Claims5