Method for describing the physical distribution of an agent in a patient
AssigneePEM Technologies, Inc.
InventorIrving N. Weinberg
Life of this patent
Estimating the term…
Abstract
A system for describing the physical distribution of an agent that accumulates selectively in tissue of a patient in an excised surgical specimen. The system comprises an agent which selectively concentrates in a cancer or precancer or focus of infection or other pathological condition. The system comprises a detector sensitive to the agent which is present in the surgical specimen. The system also comprises an apparatus capable of forming an image based on the information gathered by the detector, and which image describes the physical distribution of the agent in the surgical specimen so that a surgeon can be guided by the image provided by the apparatus, the apparatus connected to said detector.
Claims16
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the method further includes the step of providing the holder with fiduciary markings.
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the agent is a radiotracer and the receptor is sensitive to radiation emitted by the agent.
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the agent is capable of distorting an electromagnetic field and the receptor detects distorted electromagnetic fields;
- and
- wherein the agent is bromodeoxyuridine.
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the method further includes the step of displaying the derived image.
A method for near real-time determination of the presence and distribution of an agent in cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the position of the specimen holder is recorded during said determination.
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen;
- wherein the method further includes the step of compressing the tissue specimen to optimize spatial resolution of the image.
A method for near real-time imaging of cancerous, precancerous or abnormal cells in a tissue specimen of a subject comprising the steps of:
- administering to the subject an agent that selectively concentrates in the cancerous, precancerous or abnormal cells;
- excising a tissue specimen from a subject;
- slicing the tissue specimen;
- arranging the slices on a specimen holder;
- sealing the specimen holder;
- placing a receptor in close proximity to the holder to determine the presence and concentration of the agent in the tissue specimen;
- and
- deriving an image of an area of interest in the tissue specimen based on information provided by the receptor regarding the presence and concentration of the agent in the tissue specimen,
- wherein the method further includes the step of obtaining an x-ray image of the tissue specimen in the holder.
Dependencies are inferred from the claim text.