Composition for enhancing cellular immunogenicity comprising alpha-glycosylceramides

A method for treating virus infections in a mammal in need thereof, comprising:

• administering to the mammal an effective amount of the virus infected cell that has been in in vitro contact with the compound of formula (I):
• wherein
• R1 represents H or OH,
• X represents an integer between 7 and 27,
• R2 represents a substituent selected from the group consisting of the following (a) to (e) (wherein Y represents an integer between 5 and 17):
• (a) —CH2(CH2)YCH3
• (b) —CH(OH)(CH2)YCH3
• (c) —CH(OH)(CH2)YCH(CH3)2
• (d) —CH═CH(CH2)Y(CH3)
• (e) —CH(OH)(CH2)YCH(CH3)CH2CH3, and
• R3 to R9 represent substituents as defined in any one of the following i) and ii):
• i) when R3, R6 and R8 represent H,
• R4 represents H, OH, NH2, NHCOCH3, or a substituent selected from the group consisting of the following groups (A) to (D):
• R5 represents OH or a substituent selected from the group consisting of the following groups (E) and (F):
• R7 represents OH or a substituent selected from the group consisting of the following groups (A) to (D):
• R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (A′) to (D′):
• ii) when R3, R6 and R7 represent H,
• R4 represents H, OH, NH2, NHCOCH3, or substituent selected from the group consisting of the following groups (A) to (D):
• R5 represents OH or a substituent selected from the group consisting of groups (E) and (F):
• R8 represents OH or a substituent selected from the group consisting of the following groups (A) to (D):
• R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (A′) to (D′):
• or a salt or solvate thereof.

A method for treating pathogen infections in a mammal in need thereof, comprising:

• administering to the mammal an effective amount of the pathogen infected cell that has been in in vitro contact with the compound of formula (I):
• wherein
• R1 represents H or OH,
• X represents an integer between 7 and 27,
• R2 represents a substituent selected from the group consisting of the following (a) to (e) (wherein Y represents an integer between 5 and 17):
• (a) —CH2(CH2)YCH3
• (b) —CH(OH)(CH2)YCH3
• (c) —CH(OH)(CH2)YCH(CH3)2
• (d) —CH═CH(CH2)Y(CH3)
• (e) —CH(OH)(CH2)YCH(CH3)CH2CH3, and
• R3 to R9 represent substituents as defined in any one of the following i) and ii):
• i) when R3, R6 and R8 represent H,
• R4 represents H, OH, NH2, NHCOCH3, or a substituent selected from the group consisting of the following groups (A) to (D):
• R5 represents OH or a substituent selected from the group consisting of the following groups (E) and (F):
• R7 represents OH or a substituent selected from the group consisting of the following groups (A) to (D):
• R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (A′) to (D′):
• ii) when R3, R6 and R7 represent H,
• R4 represents H, OH, NH2, NHCOCH3, or substituent selected from the group consisting of the following groups (A) to (D):
• R5 represents OH or a substituent selected from the group consisting of groups (E) and (F):
• R8 represents OH or a substituent selected from the group consisting of the following groups (A) to (D):
• R9 represents H, CH3, CH2OH or a substituent selected from the group consisting of the following groups (A′) to (D′):
• or a salt or solvate thereof.