Sialyltransferase and DNA encoding the same
AssigneeSeikagaku Kogyo Kabushiki Kaisha
InventorMasaki Saito
Life of this patent
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Abstract
A sialyltransferase having the following physico-chemical properties: (1) Activity: transfers sialic acid from a sialic acid donor selectively to a 3-hydroxyl group of a galactose residue contained in lactosylceramide as a sialic acid acceptor to produce ganglioside GM3; (2) Optimal reaction pH: 6.0 to 7.0; and (3) Inhibition and activation: the activity increases at least 1.5 times with 10 mM of Mn2+ as compared with the case in the absence thereof.
Claims3
An isolated DNA which has a nucleotide sequence shown by SEQ ID NO:
- 1.
A recombinant vector comprising the DNA comprising a nucleotide sequence shown by SEQ ID NO:
- 1.
A transformant into which a DNA is introduced, and in which the DNA can be expressed, said DNA comprising a nucleotide sequence shown by SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.