Method of stable integration of DNA into neurons
AssigneeSpinal Cord Society
InventorsToomas Neuman, Howard O. Nornes
Life of this patent
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Abstract
The invention relates to the stable transfection of neurons with DNA encoding proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Also, co-transfection of a functional gene along with the DNA encoding PCNA and RFC causes stable integration of the functional gene.
Claims13
A set of vectors for inducing a differentiated cell to express introduced DNA encoding a desired protein, the set of vectors comprising:
- DNA encoding a desired protein, nucleic acid encoding proliferating cell nuclear antigen (PCNA), and nucleic acid encoding replication factor C (RFC).
A set of vectors for inducing a differentiated cell to express introduced DNA encoding a desired protein, the set of vectors comprising:
- nucleic acid encoding proliferating cell nuclear antigen (PCNA) and nucleic acid encoding replication factor C (RFC).
A combination of nucleic acids for inducing a differentiated cell to express introduced DNA encoding a desired protein, the combination comprising nucleic acid encoding proliferating cell nuclear antigen (PCNA) and nucleic acid encoding replication factor C (RFC).
Dependencies are inferred from the claim text.