Capsid-modified recombinant adenovirus and methods of use
AssigneeThe UAB Research Foundation
InventorDavid T. Curiel
Life of this patent
Estimating the term…
Abstract
The present invention describes a recombinant adenoviral vector in which a single-chain antibody has been introduced into the minor capsid proteins, pIIha or pIX, so that the adenoviral vector can be targeted to a particular cell type. Additionally disclosed is a method of using the recombinant adenoviral vector in targeted gene therapy.
Claims9
A recombinant adenovirus comprising a modified minor capsid protein gene selected from the group consisting of a minor capsid protein pIIIa gene modified by inserting a DNA sequence encoding a peptide into the 5′ end of said pIIIa gene and a minor capsid protein pIX gene modified by inserting a DNA sequence encoding a single chain antibody into the 3′ end of said pIX gene.
Dependencies are inferred from the claim text.