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AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsSally E. Spence, Jeffrey S. Smith, Jonathan R. Keller
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The present invention provides a composition for targeted delivery of a nucleic acid to a cell comprising a biotinylated recombinant adenovirus, wherein biotin is covalently linked to the recombinant adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the recombinant adenovirus is linked via streptavidin to a biotinylated targeting moiety. Also provided by this invention is a method for targeted delivery of a nucleic acid to a selected cell in a subject comprising administering to the subject a composition comprising a biotinylated recombinant adenovirus, wherein biotin is covalently linked to the recombinant adenovirus, wherein the recombinant adenovirus comprises the nucleic acid, and wherein the recombinant virus is linked via streptavidin to a biotinylated targeting moiety that specifically targets the selected cell.
A composition comprising a biotinylated recombinant adenovirus that comprises a nucleic acid, wherein biotin is covalently linked to the recombinant adenovirus, and wherein the recombinant adenovirus is linked via streptavidin to a biotinylated targeting moiety.
A composition comprising a biotinylated recombinant encapsidated virus that comprises a nucleic acid, wherein biotin is covalently linked to the recombinant virus, and wherein the recombinant virus is linked via streptavidin to a biotinylated targeting moiety.
Dependencies are inferred from the claim text.