Isolated human enzyme proteins, nucleic acid molecules encoding human enzyme proteins, and uses thereof
AssigneeApplera Corporation
InventorsEllen M. Beasley, Gennady V. Merkulov, Valentina Di Francesco
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Abstract
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the enzyme peptides, and methods of identifying modulators of the enzyme peptides.
Claims23
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:2;
- (b) a nucleotide sequence consisting of SEQ ID NO:1;
- (c) a nucleotide sequence consisting of SEQ ID NO:3;
- and
- (d) a nucleotide sequence that is completely complementary to a nucleotide sequence of(a)-(c).
An isolated polynucleotide consisting of the nucleotide sequence set forth in SEQ ID NO:1.
An isolated polynucleotide consisting of the nucleotide sequence set forth in SEQ ID NO:3.
An isolated nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes SEQ ID NO:2;
- (b) SEQ ID NO:1;
- (c) residues 199-1287 of SEQ ID NO:1;
- (d) SEQ ID NO:3;
- and
- (e) a nucleotide sequence that is completely complementary to a nucleotide sequence of (a)-(d).
An isolated nucleic acid molecule consisting of a nucleotide sequence selected from the group consisting of:
- (a) a nucleotide sequence that encodes a trans-prenyltransferase having at least 99% amino acid sequence identity to SEQ ID NO:2;
- (b) a nucleotide sequence having at least 99% sequence identity to SEQ ID NO:1, wherein said nucleotide sequence encodes a trans-prenyltransferase;
- and
- (c) a nucleotide sequence that is completely complementary to a nucleotide sequence of (a)-(b).
Dependencies are inferred from the claim text.