Method for identifying compounds altering higher-order chromatin-dependent chromosome stability
AssigneeBoehringer Ingelheim International GmbH
InventorsThomas Jenuwein, Stephen Rea, Frank Eisenhaber, Dónal O'Carroll
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Abstract
A method for identifying compounds that alter higher order chromatin dependent chromosome stability is based on determining the compounds' ability to modify a methyltransferase with Suv39h-like methyltransferase activity. The identified compounds are useful in therapy, in particular the therapy of human cancer and for contraception.
Claims12
A method for identifying a candidate compound that alters higher order dependent chromosome stability in mitosis and meiosis, said method comprising incubating a substrate for a methyltransferase, in the presence of a methyl donor, with a methyltransferase selected from human SUV39H2, murine Suv39h1, and murine Suv39h2 in the presence or absence of a test compound and determining whether the compound modulates the methyltransferase activity, wherein said modulation is indicative that said candidate compound alters higher order dependent chromosome stability in mitosis and meiosis.
Dependencies are inferred from the claim text.