Antibodies for inhibiting blood coagulation and methods of use thereof
AssigneeSunol Molecular Corporation
InventorsHing C. Wong, Jin-An Jiao, Esperanza Liliana Nieves, Lawrence Luepschen
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Abstract
The invention includes antibodies that provide superior anti-coagulant activity by binding native human TF with high affinity and specificity. Antibodies of the invention can effectively inhibit blood coagulation in vivo. Antibodies of the invention can bind native human TF, either alone or present in a TF:VIIa complex, effectively preventing factor X binding to TF or that complex, and thereby reducing blood coagulation. Preferred antibodies of the invention specifically bind a conformational epitope predominant to native human TF, which epitope provides an unexpectedly strong antibody binding site.
Claims40
An antibody that binds native human tissue factor to form a complex whereby factor X binding to the complex is inhibited, wherein the antibody is chimeric and comprises a constant region of human origin.
An antibody that binds native human tissue factor to form a complex whereby factor X binding to the complex is inhibited, wherein the antibody is chimeric and comprises a constant region of human origin,
- the antibody comprising hypervariable region represented SEQ ID NOS. 5 through 10 inclusive.
An antibody that binds native human tissue factor to form a complex whereby factor X binding to the complex is inhibited.
An humanized chimeric antibody that binds native human tissue factor to form a complex whereby factor X binding to the complex is inhibited.
Dependencies are inferred from the claim text.