Process for making absorbable microparticles

A process for making an encased bound microparticle or microparticles wherein the encased bound microparticle or microparticles comprise bound microparticle or microparticles and an absorbable encasing polymer where

• the bound microparticle or microparticles comprise an absorbable heterochain polymer core and one or more peptide, one or more protein or a combination thereof ionically immobilized on said absorbable heterochain polymer core where each peptide is independently selected from growth hormone releasing peptide (GHRP), luteinizing hormone-releasing hormone (LHRH), somatostatin, bombesin, gastrin releasing peptide (GRP), calcitonin, bradykinin, galanin, melanocyte stimulating hormone (MSH), growth hormone releasing factor (GRF), amylin, tachykinins, secretin, parathyroid hormone (PTH), enkaphelin, endothelin, calcitonin gene releasing peptide (CGRP), neuromedins, parathyroid hormone related protein (PTHrP), glucagon, neurotensin, adrenocorticothrophic hormone (ACTH), peptide YY (PYY), glucagon releasing peptide (GLP), vasoactive intestinal peptide (VIP), pituitary adenylate cyclase activating peptide (PACAP), motilin, substance P, neuropeptide Y (NPY), TSH and analogs and fragments thereof or a pharmaceutically acceptable salt thereof;
• and where each protein is independently selected from growth hormone, erythropoietin, granulocyte-colony stimulating factor, granulocyte-macrophage-colony stimulating factor and interferons;
• said process comprising the steps of:
• obtaining a dispersion, where the dispersion comprises solid bound microparticles in a solution of the absorbable encasing polymer, by homogenizing and concurrently dispersing said solid bound microparticles into the solution of an absorbable encasing polymer;
• and
• nebulizing said dispersion through a nebulization probe into a liquid, non-solvent of said absorbable encasing polymer at a flow rate of about 1 ml/min to 15 ml/min wherein said non-solvent is maintained at a temperature of about room temperature to about −80° C. and said probe has an operating ultrasonic frequency range of 12 kHz to 36 kHz.